Antihypertensive Effect of Simvastatin in Hypertensive Patients
- Registration Number
- NCT00704548
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Brief Summary
Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive effect may explain part of the favorable results of the Statins use on cardiovascular prevention independently from its action on the cholesterol profile.
The purpose of this study is to determine the effect of Simvastatin on the blood pressure
- Detailed Description
This is a randomized double blind parallel clinical trial where hypertensive patients with controlled or uncontrolled blood pressure and without evidence of target-organ damage will be selected. Subjects will receive Simvastatin 40 mg once daily or placebo and a baseline and eight weeks ABPM will performed. The main outcome will be the difference in systolic BP in the 24h-ABPM.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 92
- Hypertensive patients with controlled or uncontrolled blood pressure
- Secondary causes of hypertension;
- Systolic Blood pressure >= 180 mmHg and/or diastolic blood pressure >= 110 mmHg
- Complain of side effects related to Statins
- Diabetes
- Established target-organ damage (myocardial infarction, stroke, angina, heart failure, peripheral vascular disease)
- Renal disease (creatinine > 1,5 mgdl).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Simvastatin 40mg Simvastatin 40 mg 2 Placebo -
- Primary Outcome Measures
Name Time Method Blood Pressure measured with 24-Ambulatory Blood Pressure Monitoring (24h-ABPM) Eigth weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande do Sul, Brazil