Effect of Hydroxycitrate on Urine Chemistry
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- NYU Langone Health
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- changes in urinary excretion of citrate
Study Overview
Brief Summary
Hydroxycitrate (HCA) is a compound extracted from the fruit, Garcinia Cambogia. Hydroxycitrate supplements are available over the counter and are primarily promoted as a weight loss supplement. There has been recent evidence that hydroxycitrate is a potent inhibitor of calcium oxalate crystal growth and can lead to the dissolution of the crystals. The purpose of this research study is to study the effect of Hydroxycitrate (HCA) supplements on HCA urinary excretion and on urine chemistries in kidney stone formers and normal subjects.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Stone formers group:
- •Established diagnosis of recurrent calcium stone formers
- •Ages between 18 and 80
- •Subjects must be able to read and follow instructions clearly and able to do 24 hour urine collections.
- •Subjects must be voluntarily willing and able to sign an informed consent form.
- •Control Group:
- •In addition to b, c and d above, subjects must not have any known kidney disease or family history of renal stones. Inclusion would be based on information provided by participants.
Exclusion Criteria
- Not provided
Arms & Interventions
Control Group
Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet. HCA will be administered afterwards to both groups (see methods below) for 7 days
Intervention: Hydroxycitrate (HCA) (Dietary Supplement)
Calcium Stone Formers
Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet. HCA will be administered afterwards to both groups (see methods below) for 7 days
Intervention: Hydroxycitrate (HCA) (Dietary Supplement)
Outcomes
Primary Outcomes
changes in urinary excretion of citrate
Time Frame: 7 Days
Paired t-tests will be performed to compare any changes in citrate before and after the intervention.
Secondary Outcomes
No secondary outcomes reported