Droxidopa in Treating Patients With Neurogenic Hypotension

Not Applicable

Completed

• Conditions: Shy-Drager Syndrome; Orthostatic Hypotension

• Registration Number: NCT00004478
• Lead Sponsor: Icahn School of Medicine at Mount Sinai

Brief Summary

Please note that the continuation study can be found at http://clinicaltrials.gov/show/NCT00633880.

RATIONALE: Neurogenic hypotension is a fall in blood pressure that occurs when one moves from a lying down to a standing position or after eating a meal. It causes one to feel dizzy, light headed, and weak. Neurogenic hypotension is caused by a problem in the part of the nervous system that controls such functions as heart rate and blood pressure. Droxidopa, a drug that may increase blood pressure, may be an effective treatment for neurogenic hypotension.

PURPOSE: Clinical trial to study the effectiveness of droxidopa in treating patients who have neurogenic hypotension.

Detailed Description

PROTOCOL OUTLINE:

Patients receive escalating doses of droxidopa or placebo for 7-14 days. Patients undergo blood pressure measurements hourly in both supine and standing positions.

Study Timeline

• Study Start: 1999-03
• Study First Submitted: 1999-10-18
• Study First Submitted QC: 1999-10-18
• Study First Posted: 1999-10-19
• Primary Completion: 2006-03
• Study Completion: 2006-03
• Status Verified: 2008-09
• Last Update Submitted: 2008-09-17
• Last Update Posted: 2008-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

New York University School of Medicine; 🇺🇸 New York, New York, United States