The University of Michigan PCOS Intervention Using Nutritional Ketosis
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Mean Percent Body Weight Loss
研究概览
简要总结
The goal of this proposal is to pilot test our existing very-low carbohydrate diet intervention, adapted for women with PCOS.
详细描述
Polycystic ovary syndrome (PCOS) is a common and costly ($4.3 billion/year) endocrine disorder that significantly impairs quality of life and increases the risk of obesity and type 2 diabetes as well as hyperandrogenism, infertility, hyperlipidemia, and cardiovascular disease. Diet and lifestyle weight-loss interventions are recommended as the first-line treatment of PCOS, but experts disagree about which nutritional approach is best. A review of previous diet and lifestyle trials in PCOS did find a slight benefit of lower carbohydrate diets for weight loss, glucose control, insulin, and insulin resistance. This may be because carbohydrate intake leads to increased insulin secretion, which then stimulates ovarian androgen production and inhibits the release of fatty acids from cells, both of which worsen PCOS-related issues. Although lower carbohydrate diets may be helpful, research from other populations with or at risk of type 2 diabetes suggests that prior PCOS studies may have set insufficient carbohydrate reduction targets. The investigators propose that a very-low carbohydrate diet may be needed to especially benefit women with PCOS, as greater carbohydrate reduction should have a larger impact on androgen levels and weight loss. Thus, the goal of this proposal is to pilot test our existing very-low carbohydrate diet intervention, adapted for women with PCOS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Laboratory results will be assessed by a lab not associated with the study team.
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •We will include women in one PCOS subtype, those having these two symptoms:
- •Hyperandrogenism - (a) If not on current birth control: hyperandrogenism defined as current elevated total testosterone >= 50 ng/dL or free androgen index > 1.5 (ratio of testosterone/SHBG x 100) or severe acne or hirsutism (b) if on current birth control: history from the past 10 years of hyperandrogenism defined as past elevated total testosterone >= 50 ng/dL or free androgen index > 1.5 (ratio of testosterone/SHBG x 100) or severe acne or hirsutism
- •oligomenorrhea-anovulation defined as spontaneous intermenstrual periods of ≥ 45 days or a total of ≤ 8 menses per year.
- •Participants must also be:
- •overweight or obese (BMI 25-50)
- •be 21-40 years old
- •have regular access to the internet
- •be able to engage in light physical activity
- •willing and able to follow the assigned intervention.
排除标准
- •a non-English speaker
- •inability to complete baseline measurements
- •a substance abuse, mental health, or medical condition that would interfere with participation (such as current chemotherapy)
- •pregnant or planning to get pregnant in the next 6 months
- •type 1 or type 2 diabetes
- •baseline aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2 times normal
- •baseline renal disease defined as BUN > 30 mg/dL or serum creatinine >1.4 mg/dL
- •baseline uncorrected thyroid disease (TSH <0.45 mIU/ML or >4.5 mIU/ML)
- •breastfeeding or less than 6 months post-partum
- •planned or history of weight loss surgery
- •vegan or vegetarian
- •currently enrolled in a weight loss program or other investigative study that might conflict with this research
- •taking medications known to cause weight gain or loss
- •taking hypoglycemic medications other than metformin or medications known to affect metabolism
- •or patients with other etiologies of anovulation and hyperandrogenism, e.g., Cushing's disease, thyroid dysfunction, elevated prolactin levels, signs of congenital adrenal hyperplasia, organic intra cranial lesion such as a pituitary tumor, or suspected adrenal or ovarian tumor secreting androgens.
结局指标
主要结局
Mean Percent Body Weight Loss
时间窗: 4 months
Mean percent body weight loss was defined as: (weight at 4 months - baseline weight) / (baseline weight) \*100.
次要结局
- HbA1c Change(4 months)
研究者
Laura Saslow
Assistant Professor
University of Michigan