Comparison of Mg, Ketamine, Large Dose Rocuronium, and Priming on Intubating Condition in Rapid Sequence Intubation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- Intubation score
Study Overview
Brief Summary
In this study, methods which are known for facilitating rapid sequence intubation or accelerating rocuronium (Roc)onset are compared including magnesium (Mg), ketamine pretreatment, large dose rocuronium and priming.
Detailed Description
Patients are pretreated with Mg, ketamine, or priming dose Roc. Two groups do not receive pretreatment, but are given Roc 0.6 mg/kg or 0.9 mg/kg.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age 18 - 65 years,
- •ASA 1 - 2,
- •patients scheduled for elective surgery under general anesthesia,
- •BMI 18.5-24.9 kg/m2
- •Mallampati class I-II
Exclusion Criteria
- •neuromuscular disorder,
- •cardiac/hepatic/renal insufficiency,
- •pregnant.
- •anticipated difficult airway
- •medications that influence neuromuscular transmission
Arms & Interventions
priming
Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg.
Intervention: rocuronium (Drug)
ketamine
Patients receive ketamine 0.5 mg/kg 2 min before Roc injection.
Intervention: Ketamine (Drug)
Mg
Patients receive magnesium sulfate (MgSO4) 50 mg/kg over 10 min before Roc injection.
Intervention: Magnesium Sulfate (Drug)
Outcomes
Primary Outcomes
Intubation score
Time Frame: participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection.
Patients are tracheally intubated, and intubation scores(poor, good,excellent)are rated.
Secondary Outcomes
- Roc onset(participants will be followed when TOFcount =0 within an expected average of 4 min from the start of rocuronium injection.)
- Roc duration(participants will be followed when TOF count reaches two, an expected average of 40 min.)
- Hemodynamic variables(participants will be followed at baseline, before and for 5 min after the intubation, an expected average of 8 min after the start of anesthetic induction.)
- TOF% at intubation(participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection.)
Investigators
Kim Mihyun
clinical professor
Seoul National University Bundang Hospital