NL-OMON20240尚未招募不适用
ow dose iron chelation as TReatment of Oxidative damage in Sickle cell disease; TROS study
Amsterdam UMC location AMC.0 个研究点目标入组 10 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- •1.High performance liquid chromatography confirmed diagnosis of HbSS or HbSß0 geno-type.
- •2.Aged 18-65 years
- •3.Written informed consent
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •1.Blood transfusion in the preceding four months
- •2.Already using iron chelation due to iron overload
- •3.Ferritin levels of <50 µg/L and/or transferrin saturation of < 0.20.
- •4.LDH of < 300 U/L
- •5.Pregnancy or the desire to get pregnant in the following 6 months
- •6.Impaired renal function of GFR < 60 ml/min/1,73m2 (CKD-EPI).
- •7.Known allergic reaction to deferasirox.
- •8.Other somatic or cognitive condition disturbing adherence to study treatment
研究者
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