EUCTR2020-004995-17-NL进行中（未招募）1 期
ow dose iron chelation as TReatment of Oxidative stress in Sickle cell disease; TROS study - TROS study
AMsterdam UMC-AMC0 个研究点目标入组 30 人开始时间: 2021年3月8日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •1. Sickle cell disease diagnosis: HbSS, or HbSß0-thalassemia genotype
- •2. Age 18-65 years
- •3. Willing and able to provide written informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 30
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1. Blood transfusion in the preceding four months
- •2. Already using iron chelation due to iron overload
- •3. Ferritin levels of <50 µg/L and/or transferrin saturation of < 0.20.
- •4. LDH of < 300 U/L
- •5. Pregnancy or the desire to get pregnant in the following 6 months
- •6. Impaired renal function of GFR < 60 ml/min/1,73m2 (CKD-EPI).
- •7. Known allergic reaction to deferasirox.
- •8. Other somatic or cognitive condition disturbing adherence to study treatment
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