Comparison of ACT Between Hemochron Jr and ACT Plus

Not Applicable

Completed

• Conditions: Cardiac Disease

• Registration Number: NCT02484157
• Lead Sponsor: Hallym University Medical Center

Brief Summary

This study aimed to compare 2 activated clotting time analysers (Hemochron Jr vs. ACT Plus).

Detailed Description

Measurement of activated clotting time (ACT) is a standard method for anticoagulation monitoring. Especially in cardiac surgery, heparin is usually used as anticoagulant and protamine is used to reverse anticoagulation effect at the end of surgery. ACT method defines the time until a clot is formed in a test tube after triggering of internal pathway coagulation using blood activating agents (eg. kaolin).

Acute normovolemic hemodilution (ANH) consists of withdrawing patient's blood volume early in the operative period and concurrent infusion of crystalloid or colloid to maintain intravascular volume, and is used in cardiac surgery. ANH is known to affect hemostasis in some studies.

Assuming that accurate monitoring of coagulation therapy is important to prevent both thrombotic and hemorrhagic complications, we compared ACT results from 2 analysers (Hemochron Jr and ACT Plus) in patients undergoing cardiac surgery using ANH.

Study Timeline

• Status Verified: 2012-12
• Study Start: 2012-12
• Primary Completion: 2013-12
• Study Completion: 2014-01
• Study First Submitted: 2015-06-25
• Study First Submitted QC: 2015-06-26
• Last Update Submitted: 2015-06-26
• Study First Posted: 2015-06-29
• Last Update Posted: 2015-06-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Patients who underwent cardiac surgery with heparin administration.

Exclusion Criteria

• Preoperative hemoglobin under 11g/dL
• Weight under 40kg
• Preoperative coagulopathy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Comparison of activated coagulation time between Hemochron Jr and ACT Plus	During cardiac surgeris (within 8 hours)

Trial Locations

Locations (1)

Hallym University Sacred Heart Hospital; 🇰🇷 Anyang-si, Gyeonggi-do, Korea, Republic of