Assessment of the changes in brainâ??s blood flow using a CT scan procedure called perfusion CT imaging before and following temporary and partial resection of skull to reduce brain swelling in large, life threatening brain damage due to occlusion of an artery called middle cerebral artery.
Not Applicable
- Conditions
- Health Condition 1: G819- Hemiplegia, unspecified
- Registration Number
- CTRI/2020/12/029645
- Lead Sponsor
- Sreekesh P V
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Participants with clinical and radiological features suggestive of malignant middle cerebral artery infarct (infarct involving >50 % of middle cerebral artery territory or presence of midline shift >5mm on plain CT scan or fall in admission GCS by 1 point) who undergo decompressive craniectomy within 48 hours of ictus.
Exclusion Criteria
1.Participants with deranged renal parameters and history of radiocontrast allergy
2.Participants who are unfit for surgery.
3.Participants who are pregnant.
4.Participants with previous history of stroke.
5.Participants with intracerebral hemorrhage on initial CT scan.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Perfusion CT parameters <br/ ><br>1.Mean Transit Time (MTT) <br/ ><br>2.Cerebral Blood Flow (CBF) <br/ ><br>3.Cerebral Blood Volume (CBV) <br/ ><br>Timepoint: Before and within 24 hours after decompressive craniectomy
- Secondary Outcome Measures
Name Time Method 30day outcome by modified Rankin ScaleTimepoint: 30 days after decompressive craniectomy