The direct effect of cerebral blood flow perturbations on cerebral perfusion and cognitive performance in healthy elderly people

Completed

• Conditions: mild cognitive impairment; mild memory problems; 10012272

• Registration Number: NL-OMON42934
• Lead Sponsor: Geriatrie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

Males and females aged >=60
Living independently at home
Physical ability sufficient to allow performance of exercise
Normal or corrected-to-normal vision
Stable medical condition for more than 6 months
Stable medications for more than 2 months

Exclusion Criteria

Experience of subjective memory problems
History of serious neurological disorder
History of any major psychiatric disorder
Significant history of alcoholism or drug abuse within the last 10 years
History of myocardial infarction within previous year
Unstable cardiac, renal, lung, liver, or other chronic disease
Uncontrolled hypertension or hypotension
Congestive heart failure (NYHA class II, III or IV)
Diabetes
Use of psychopharmacological drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in functional prefrontal activation as determined by oxygenated<br /><br>hemoglobin changes (µmol/L) induced by cerebral blood flow perturbations. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>