The background of the reduced cerebral blood flow in Duchenne muscular dystrophy
Completed
- Conditions
- duchenne muscular dystrophyDuchenne's Disease10028302
- Registration Number
- NL-OMON50456
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 27
Inclusion Criteria
* Age over 10 years (DMD) or 12 years (healthy)
* Male
* Ambulant
For patients only:
- a mutation in the DMD gene that affects both Dp427 and Dp140
Exclusion Criteria
* No informed consent
* Medical history of CV disease, diabetes mellitus, neurological disease (other
than DMD)
* History of recurrent syncope
* Joint contractures preventing the use of the HUT
* Contraindication to MRI exposure (*vragenlijst MRI onderzoek*)
* Inability to lie supine for at least 45 minutes
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary end-points of this study are differences in systemic blood<br /><br>pressure, global cerebral blood flow velocity and local cerebral perfusion<br /><br>between healthy controls and patients with DMD.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Systolic / diastolic blood pressure<br /><br>- Heart rate<br /><br>- Total peripheral resistance<br /><br>- End-tidal CO¬2 content (PetCO¬2)<br /><br>- Blood volume shift<br /><br>- Sustained attention to response task score and regional brain blood flow<br /><br>response<br /><br>- General intellectual function based on PPVT<br /><br>- Response time and pressing endurance measured with FePsy<br /><br>- Cardiac function: stroke volume and shortening fraction of left ventricle</p><br>