The cardiac contribution to cerebral perfusion - 'the heart-brain axis'
Completed
- Conditions
- circulationblood flow10057166
- Registration Number
- NL-OMON41298
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 86
Inclusion Criteria
* Age between 18 to 30 years (younger subjects), age between 50 to 60 years (older subjects) or age 75 years and older (old subjects)
Exclusion Criteria
* Frail elderly (presence of *3 criteria: weight loss, weakness, poor endurance/exhaustion, slowness, low physical activity)
* Medical history of CV disease, hypertension, diabetes mellitus, pulmonary disease, neurological disease, malignant disease and/or venous insufficiency
* Abnormal lab results (medical screening)
* Stenosis of (one of) the carotid arteries (retrospectively)
* Abnormal ECG (medical screening)
* Use of systemic medication
* Any cognitive impairment (MMSE>24 points)
* Contraindication to MRI exposure
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary end-points of this study are systemic blood flow and cerebral<br /><br>perfusion.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Blood pressure<br /><br>- Cardiac output<br /><br>- Age<br /><br>- Cerebrovascular reactivity </p><br>