Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer
- Conditions
- Pancreatic Cancer
- Registration Number
- NCT00010062
- Lead Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells left after surgery.
PURPOSE: Phase II trial to study the effectiveness of combining fluorouracil and radiation therapy in treating patients who have undergone surgery for pancreatic cancer.
- Detailed Description
OBJECTIVES:
* Determine the tolerance of adjuvant fluorouracil with concurrent radiotherapy in patients with resected pancreatic adenocarcinoma.
* Determine survival without local relapse in these patients treated with this regimen.
* Determine overall survival of these patients treated with this regimen.
* Determine the effectiveness of this adjuvant therapy in these patients.
OUTLINE: This is a multicenter study.
Patients receive high-dose radiotherapy 5 days a week for 5 weeks. Patients also receive low-dose radiotherapy 4 times a week during the last 2 weeks of the 5-week course of treatment. Patients concurrently receive fluorouracil IV continuously for 5 weeks in the absence of disease progression or unacceptable toxicity.
Patients are followed for survival.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (29)
Clinique De Savoie
🇫🇷Annemasse, France
Clinique Floreal
🇫🇷Bagnolet, France
Clinique Tivoli
🇫🇷Bordeaux, France
Centre Regional Francois Baclesse
🇫🇷Caen, France
Clinique Saint - Jean
🇫🇷Cagne-sur-Mer, France
Polyclinique Saint Jean
🇫🇷Cagnes Sur Mer, France
Hopital Fontenoy
🇫🇷Chartres, France
Hopital Beaujon
🇫🇷Clichy, France
Hopital Louis Mourier
🇫🇷Colombes, France
Hopital Drevon
🇫🇷Dijon, France
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