Cognitive-motor Exercise for Stroke Patients in Function, Cognition and Related Brain Changes.

Not Applicable

Recruiting

• Conditions: Stroke
• Interventions: Behavioral: Single-task training; Behavioral: Upper limb strengthening exercise; Behavioral: Dual-task training

• Registration Number: NCT06362512
• Lead Sponsor: The Hong Kong Polytechnic University

Brief Summary

The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.

Detailed Description

The prevalence rate of stroke increased by 106.0% (93.7-118.8) from 1990 to 2019 in China, and stroke burden is still severe. Community ambulation is an important factor that influences health-related quality of life after a stroke.In daily living, effective community ambulation requires the ability to maintain balance and walking function while engaging in other tasks that demand attentional resources simultaneously (i.e., dual-tasking). Increasing evidence has shown that stroke patients have more problems with dual-task balance and walking function than their age-matched able-bodied peers. stroke individuals were found to have more reduction in both the walking speed and cognitive recall than control group during walking with remembering a shopping list. Hence, since stroke victims must reintegrate into community, this kind of cognitive-motor interference needs to be thoroughly studied.

Study Timeline

• Status Verified: 2024-04
• Study First Submitted: 2024-04-08
• Study First Submitted QC: 2024-04-08
• Study First Posted: 2024-04-12
• Study Start: 2024-06-17
• Last Update Submitted: 2024-07-02
• Last Update Posted: 2024-07-05
• Primary Completion: 2026-04
• Study Completion: 2026-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
single-task group	Single-task training	Patients receive three separate cognitive and mobility exercises per week for six weeks.
control group	Upper limb strengthening exercise	Patients receive three upper limb muscle strengthening exercise with muscle stretching per week for six weeks.
dual-task group	Dual-task training	patients receive three dual motor-cognitive exercise training per week for six weeks.

Primary Outcome Measures

Name	Time	Method
Dual-task step frequency	before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training	step frequency under dual-task condition will be recorded
Dual-task cognitive performance accuracy	before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training	Number of correct responses will be measured during dual-task conditions

Secondary Outcome Measures

Name	Time	Method
Blood oxygenation level changes of the brain	before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training	Blood oxygenation level changes will be measured using Magnetic Resonance Imaging during dual-task conditions
Dual-task No.steps	before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training	No.steps under dual-task condition will be recorded
Dual-task amplitude of ankle movement	before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training	Amplitude of ankle movement under dual-task condition will be recorded
Dual-task correct reaction time	before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training	Correct reaction time under dual-task condition will be recorded

Trial Locations

Locations (1)

The Hong Kong Polytechnic University; 🇨🇳 Hong Kong, China