An Innovative Cognitive-motor Exercise Training (COGMOTION) for People With Stroke: Effects on Balance, Mobility, Falls, Cognition and Related Brain Changes.
试验速览
- 阶段
- 不适用
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Dual-task step frequency
研究概览
简要总结
The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.
详细描述
The prevalence rate of stroke increased by 106.0% (93.7-118.8) from 1990 to 2019 in China, and stroke burden is still severe. Community ambulation is an important factor that influences health-related quality of life after a stroke.In daily living, effective community ambulation requires the ability to maintain balance and walking function while engaging in other tasks that demand attentional resources simultaneously (i.e., dual-tasking). Increasing evidence has shown that stroke patients have more problems with dual-task balance and walking function than their age-matched able-bodied peers. stroke individuals were found to have more reduction in both the walking speed and cognitive recall than control group during walking with remembering a shopping list. Hence, since stroke victims must reintegrate into community, this kind of cognitive-motor interference needs to be thoroughly studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
This will be a single-blinded randomized controlled trial . The assessor will be blinded during assessments. The participants and investigators (trainers) are not possible to be blinded as it is an exercise intervention.
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of stroke, Stroke onset of more than 6 months Aged 50 or more Capable of following verbal instructions Having a Montreal Cognitive Assessment score≥22, Able to walk for 1 minute without physical assistance Not receiving any formal rehabilitation training Having a Fugl-Meyer Ankle dorsiflexion-standing position score≥1
排除标准
- •Contraindications to exercise (e.g., unstable angina) Contraindications to MRI (e.g., pacemaker) Color blindness Neurological disorders Gait-precluding pain Comorbidity
研究组 & 干预措施
dual-task group
patients receive three dual motor-cognitive exercise training per week for six weeks.
干预措施: Dual-task training (Behavioral)
single-task group
Patients receive three separate cognitive and mobility exercises per week for six weeks.
干预措施: Single-task training (Behavioral)
control group
Patients receive three upper limb muscle strengthening exercise with muscle stretching per week for six weeks.
干预措施: Upper limb strengthening exercise (Behavioral)
结局指标
主要结局
Dual-task step frequency
时间窗: before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training
step frequency under dual-task condition will be recorded
Dual-task cognitive performance accuracy
时间窗: before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training
Number of correct responses will be measured during dual-task conditions
次要结局
- Dual-task No.steps(before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training)
- Dual-task amplitude of ankle movement(before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training)
- Dual-task correct reaction time(before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training)
- Blood oxygenation level changes of the brain(before the initiation of training,after 6 weeks of training, 6 weeks after termination of the training)