Maternal cardiac effect of Hydroxyethyl Starch (HES) using LiDCO in cesarean sectio

Phase 4

Completed

• Conditions: pregnancy requiring caesarean section; cardiac effect; Anaesthesiology - Anaesthetics; Reproductive Health and Childbirth - Childbirth and postnatal care; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12616000252415
• Lead Sponsor: Guang Han

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

(1) primiparas who underwent elective cesarean section (2)age of 20–30 years, (3) body weight of 60–90 kg, (4) ASA class 1–2, (5) no contraindications to spinal anesthesia.

Exclusion Criteria

(1) multiple pregnancy, (2) height less than 150 cm, (3) placenta previa, (4) complications including diabetes mellitus, hypertensive diseases in pregnancy, etc. (5) contraindication to central neural blockade (patients refusal, raised intracranial pressure, hypovolemic states, abnormal coagulopathy).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiac output (CO) assessed using LiDCO rapid (arterial pressure waveform analysis).[Baseline (T0), immediately after spinal anesthesia (T1), skin incision (T2), neonates delivery (T3), the placenta delivery (T4), immediately after injection of oxytocin on uterine muscle wall (T5), end of operation (T6) ];Mean arterial pressure (MAP) assessed using LiDCO rapid (arterial pressure waveform analysis).[Baseline (T0), immediately after spinal anesthesia (T1), skin incision (T2), neonates delivery (T3), the placenta delivery (T4), immediately after injection of oxytocin on uterine muscle wall (T5), end of operation (T6) ];Stroke volume (SV) assessed using LiDCO rapid (arterial pressure waveform analysis).[Baseline (T0), immediately after spinal anesthesia (T1), skin incision (T2), neonates delivery (T3), the placenta delivery (T4), immediately after injection of oxytocin on uterine muscle wall (T5), end of operation (T6) ]

Secondary Outcome Measures

Name	Time	Method
nausea, assessed using 5-point Likert Scale[Every 10 minutes following spinal anaesthesia for 2 hours. ];headache, assessed using VAS pain score[Every 10 minutes following spinal anaesthesia for 2 hours. ]