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Clinical Trials/NCT04029935
NCT04029935
Completed
Not Applicable

The Influence of Acute Physical Fatigue on Functional Performance Tests of the Lower Limb in a Healthy Population

Vrije Universiteit Brussel1 site in 1 country20 target enrollmentJuly 19, 2019

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Physical Fatigue
Sponsor
Vrije Universiteit Brussel
Enrollment
20
Locations
1
Primary Endpoint
Single-leg hop test
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

The main objective of this project is:

  1. To assess the influence of physical fatigue on a return-to-play test battery in a healthy population. In a later stage, these experiments could be carried out in a clinical context (e.g. in an ankle sprain population).

The researchers will use a randomized, placebo controlled, counter-balanced, cross-over design. Twenty healthy subjects will visit the lab 3 times. On the first visit (familiarisation trial), the investigators will collect the participants' characteristics. The participants will also be familiarized to the procedures and materials of the experiment during this first visit. The second and third visit contain the experimental setup and will proceed as follows: first, the participants will fill in a pre-test checklist, a mental fatigue scale (M-VAS) and motivation scale. In the mean time a little blood will be collected from the ear lobe to determine lactate and glucose levels; also, blood pressure will be checked. Next, the subjects will carry out a functional test battery (hop test, vertical jump test, Y-balance test, and a balance reaction-time test). Session rate of perceived exertion (SRPE) is measured to indicate how fatigued the participants feel due to the test battery; also, M-VAS is collected once more, as well blood lactate, glucose and blood pressure. These measures are followed by either a physical fatigue inducing task (Modified 30 seconds Wingate protocol) or time-matched control task (sitting on the bike without pedalling). Afterwards, researchers will collect blood lactate, glucose and blood pressure two times more; participants have to fill in M-VAS (2x), perform the same test battery, and fill in the SRPE scale one more time.

Heart frequency will be measured continuously during the trials.

Registry
clinicaltrials.gov
Start Date
July 19, 2019
End Date
February 3, 2020
Last Updated
6 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Romain Meeusen

Professor Dr.

Vrije Universiteit Brussel

Eligibility Criteria

Inclusion Criteria

  • Healthy (No neurological/cardiorespiratory/psychological/musculoskeletal disorders)
  • Male and female
  • No medication
  • Non-smoker
  • Between 18 and 35 years old

Exclusion Criteria

  • Back and/or lower extremity injuries during the past 6 months
  • Bone/joint abnormalities
  • Dizziness, history of loss of consciousness, any inner ear disorders
  • Nervous system disorders or dysfunctions
  • Uncorrected eye disorders/dysfunctions
  • Use of medication or any kind of drugs
  • Use of alcohol, caffeine and heavy efforts 24 hours before each trial
  • Not eating the same meal the night before and the morning of each experimental trial

Outcomes

Primary Outcomes

Single-leg hop test

Time Frame: Change in single-leg hop test for distance performance: from baseline and 20 minutes after baseline (immediately after the assigned interventions)

Single-leg hop test for distance performance

Y-balance test

Time Frame: Change in Y-balance performance: from baseline and 20 minutes after baseline (immediately after the assigned interventions)

Balance and reach performance; participants have to maintain their balance while reaching as far as possible along 3 different directions.

Vertical jump test

Time Frame: Change in vertical jump height performance: from baseline and 20 minutes after baseline (immediately after the assigned interventions)

Vertical jump height performance

Balance-reaction time test

Time Frame: Change in balance and reaction time performance: from baseline and 20 minutes after baseline (immediately after the assigned interventions)

Balance and reaction time performance; participants have to maintain their balance while reacting as fast as possible in 3 different directions.

Secondary Outcomes

  • Blood lactate(Change in blood lactate: at baseline, 10 min after baseline (immediately after the first test battery), 15 min after baseline (immediately after the assigned interventions) and 25 min after baseline (immediately after the final test battery))
  • Perception of effort (Session RPE)(Change in session RPE: at baseline (immediately after the first test battery), 15 min after baseline (immediately after the final test battery))
  • Blood glucose(Change in blood glucose: at baseline, 10 min after baseline (immediately after the first test battery), 15 min after baseline (immediately after the assigned interventions) and 25 min after baseline (immediately after the final test battery))
  • Mental fatigue Visual Analogue Scale (M-VAS)(Change in M-VAS: at baseline, 10 min after baseline (immediately after the first test battery), 15 min after baseline (immediately after the assigned interventions) and 25 min after baseline (immediately after the final test battery))
  • Self-reported motivation(At baseline: prior to the first test battery)
  • Blood pressure(Change in blood pressure: at baseline, 10 min after baseline (immediately after the first test battery), 15 min after baseline (immediately after the assigned interventions) and 25 min after baseline (immediately after the final test battery))

Study Sites (1)

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