The Effects of Fatigue on Exercise-Induced Hypoalgesia During a Dynamic Resistance Exercise
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 31
- Locations
- 2
- Primary Endpoint
- Change in Pressure Pain Threshold
Study Overview
Brief Summary
The primary purpose of this study is to compare immediate changes in pain sensitivity (pressure pain threshold) during quiet rest, low fatigue exercise, and high fatigue exercise.
Detailed Description
Participants will attend three sessions. Participants will fill out questionnaires, undergo pain sensitivity testing, and be randomly assigned to complete a high and low fatigue exercise on either the second or third session. During the exercise, participants will complete three sets of a single leg knee extension exercise with weight equivalent to 50% of their 1 repetition maximum until they report either a high or low fatigue level. Immediately before and after each set, the research team will examine immediate changes in sensitivity to pressure (pressure pain threshold).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Pain-free
- •18-60 years old
- •Participant can appropriately perform the knee extension exercise (assessed during screening)
Exclusion Criteria
- •Non-English speaking
- •Regular use of prescription pain medications
- •Current or history of chronic pain condition
- •Currently taking blood-thinning medication
- •Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
- •Any contraindication to the application of ice, such as: uncontrolled hypertension (blood pressure over 140/90 mmHg), cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
- •Known presence of cardiovascular, pulmonary, or metabolic disease
- •Current use of tobacco products
- •Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
- •Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months
Outcomes
Primary Outcomes
Change in Pressure Pain Threshold
Time Frame: Change from baseline immediately after exercise
A digital pressure algometer will be applied to the quadriceps and upper trapezius for two trials each. Participants are instructed to say "stop" or "pain" so the stimulus can be terminated "when the sensation first transitions from pressure to pain" (pain threshold). Participants will rate the pain experienced during the threshold testing using a 101-point numeric pain rate scale (NPRS) anchored with 0= no pain to 100= the most intense pain sensation imaginable immediately following each testing time.
Secondary Outcomes
- International Physical Activity Questionnaire Short Form(Baseline, pre exercise)
- Pittsburgh Sleep Quality Index(Baseline, pre exercise)
- Brief Resilience Scale(Baseline, pre exercise)
- Heat Pain Threshold(Baseline, pre exercise)
- Pain Anxiety Symptom Scale(Baseline, pre exercise)
- Fear of Pain Questionnaire 9(Baseline, pre exercise)
- Preference for and Tolerance of the Intensity of Exercise Questionnaire(Baseline, pre exercise)
- Temporal Summation(Baseline, pre exercise)
- Conditioned Pain Modulation(Baseline, pre exercise)
- Pain Catastrophizing Scale(Baseline, pre exercise)
Investigators
Abigail Wilson
Assistant Professor
University of Central Florida