Efficacy of DE-MRI-Guided Ablation vs. Conventional Catheter Ablation of Atrial Fibrillatio
Completed
- Conditions
- atrial fibrillationpalpitations10007521
- Registration Number
- NL-OMON53352
- Lead Sponsor
- niversity of Utah health Sciences Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
- Patients with persistent AF undergoing first AF ablation as per recent HRS consensus document. Persistent AF is defined by 7 days or more in AF as evidenced by either 1) rhythm strip or 2) written documentation.
- Must have some proportion of atrial fibrosis (not limited to advanced stage fibrosis).
- Able to understand and willing to sign the Informed Consent Form.
- Age * 18 years.
Exclusion Criteria
- Contraindication for DE-MRI with a full dose of Gadolinium-based contrast agent.
- Previous left atrial ablation or surgical procedure.
- Women currently pregnant.
- Mental or physical inability to take part in the study.
- Uncontrolled hypertension.
- Inability to be placed in MRI due to body mass.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To examine the efficacy of targeting atrial fibrosis tissue during an ablation<br /><br>procedure in treating persistent AF.<br /><br><br /><br>The frequencies and proportions of patients experiencing each of three<br /><br>components of the primary AA outcome:<br /><br>atrial fibrillation<br /><br>atrial flutter<br /><br>atrial tachycardia</p><br>
- Secondary Outcome Measures
Name Time Method <p>Quality of life as measured by the Toronto Score.<br /><br>A composite outcome including AA recurrence and prescription of an<br /><br>anti-arrhythmic medication, stroke, cardiovascular hospitalization, a repeat<br /><br>ablation, AA recurrence following repeat ablation</p><br>