The Effect of Vinegar on Glucose and Lipid Metabolism in Peripheral Tissues in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- Muscle glucose uptake following meal ingestion (area under the glucose uptake versus time curve-AUC)
研究概览
简要总结
This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.
详细描述
Subjects with IGT or type 2 diabetes will be randomised to consume 20ml vinegar (6% acetic acid) or placebo before a mixed meal. Plasma samples will be taken for 300min from the radial artery and from a forearm vein for measurements of glucose, insulin, triglycerides, non-esterified fatty acids (NEFA) and glycerol. Muscle blood flow will be measured with strain-gauge plethysmography. Glucose flux will be calculated as the arteriovenous difference of glucose multiplied by the blood flow rates.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy
- •Recreationally active
- •With stable body weight and diet during the last two months.
排除标准
- •Any systemic disease (besides glucose abnormalities)
- •Any medication therapy
- •Diabetic complications
结局指标
主要结局
Muscle glucose uptake following meal ingestion (area under the glucose uptake versus time curve-AUC)
时间窗: 0, 30, 60, 90, 120, 180, 240, 300 min postmeal
次要结局
- Plasma insulin levels following meal ingestion (area under the plasma concentration versus time curve-AUC)(0, 30, 60, 90, 120, 180, 240, 300 min postmeal)
- Plasma triglyceride levels following meal ingestion (area under the plasma concentration versus time curve-AUC)(0, 30, 60, 90, 120, 180, 240, 300 min postmeal)
- Plasma NEFA levels following meal ingestion (area under the plasma concentration versus time curve-AUC)(0, 30, 60, 90, 120, 180, 240, 300 min postmeal)
- Plasma glycerol levels following meal ingestion (area under the plasma concentration versus time curve-AUC)(0, 30, 60, 90, 120, 180, 240, 300 min postmeal)
- Number of participants with adverse events(300 min postmeal)
- Plasma glucose levels following meal ingestion (area under the plasma concentration versus time curve-AUC)(0, 30, 60, 90, 120, 180, 240, 300 min postmeal)
- Muscle blood flow following meal ingestion (area under the blood flow rates versus time curve-AUC)(0, 30, 60, 90, 120, 180, 240, 300 min postmeal)
研究者
Panayota Mitrou
Senior Researcher, MD, PhD
Attikon Hospital