NCT03497169已完成不适用
Bariatric Surgery and Pharmacokinetics Lisdexamphetamine: BAR-MEDS Lisdexamphetamine
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Lisdexamphetamine concentration in blood serum (area under curve (AUC))
研究概览
简要总结
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on lisdexamphetamine are investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- •Being a Norwegian citizen
排除标准
- •Having previously undergone resections in the GI-tract
结局指标
主要结局
Lisdexamphetamine concentration in blood serum (area under curve (AUC))
时间窗: From baseline to 1 year postoperatively
次要结局
未报告次要终点
研究者
研究点 (1)
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