Assessment of Portal Circulation Before and After Variceal Eradication in Patients With Liver Cirrhosis.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 52
- 主要终点
- Study the effect of variceal eradication on portal circulation, liver stiffness and Child-Pugh and MELD scores in patients with liver cirrhosis.
研究概览
简要总结
Study the effect of variceal eradication on portal circulation, liver stiffness and Child-Pugh and MELD scores in patients with liver cirrhosis.
详细描述
Portosystemic collateral circulation is a consequence of portal hypertension, which occurs in chronic liver disease and is responsible for numerous complications.
Gastric and oesophageal varices are two of common portosystemic collaterals, patients usually presented with hematemesis, melena, or both, ultimately 20% is the mortality during the first attack.
Although both band ligation and sclerotherapy are effective modalities of treatment in controlling acute variceal bleeding, in preventing future variceal bleeding as well as in eradicating varices with very few complications , their effects on portal circulation have raised concerns among hepatologist.
Information about collateral pathways is especially relevant when interventional procedures or surgery is indicated because inadvertent distribution of these vessels can cause significant bleeding.
Few studies pointed on development of new portosystemic collaterals post variceal eradication depending on abdominal computed tomography (CT ) compared to pre-variceal eradication as showed paraoesophageal varices, retro-gastric varices not visualized with endoscopy ,or large deep gastric collaterals that may increase risk for rebleeding.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Age between 18 and 70 years old.
- •Patient with documented liver cirrhosis undergoing either primary or secondary prophylactic variceal eradication.
- •Liver cirrhosis with Child-Pugh score A and B.
排除标准
- •• Age less than 18 years.
- •Have contraindications to computed abdominal CT-angiography (e.g. allergy to all suitable contrast agents, renal failure).
- •Patients with history of recent significant bleeding varices.
- •Previous history of variceal ligation, sclerotherapy, and TIPS operation.
- •Patients with isolated gastric varices.
- •Patients with HCC or other malignancies.
- •End-stage liver disease (Child score more than 9).
- •Patients with malignant portal vein thrombosis.
- •Patients with non-cirrhotic portal hypertension.
- •Patients refuse to participate in the study.
结局指标
主要结局
Study the effect of variceal eradication on portal circulation, liver stiffness and Child-Pugh and MELD scores in patients with liver cirrhosis.
时间窗: 4 years
Study the effect of variceal eradication on portal circulation and development of new portosystemic collaterals had not be found before variceal eradication in patients with liver cirrhosis
次要结局
- Study the effect of variceal eradication on liver stiffness and Child-Pugh and MELD scores in patient with liver cirrhosis(4 years)
研究者
Esraa Yousef Mohammed
Assistant Lecturer of Tropical Medicine and Gastroenterology
Assiut University