Preoperative Portal and Splanchnic Flow Measurement Using MRI

Not Applicable

Active, not recruiting

• Conditions: Liver Cirrhoses
• Interventions: Diagnostic Test: Liver MRI

• Registration Number: NCT03868397
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study aims to assess the alteration of portal and splanchnic flow using MRI after liver transplantation in patients with splenomegaly or splenic varix.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-07
• Study First Submitted: 2019-03-07
• Study First Submitted QC: 2019-03-07
• Study First Posted: 2019-03-11
• Primary Completion: 2019-07-12
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-11
• Last Update Posted: 2023-04-13
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• older than 18 years
• And signed informed consent
• And planned either a) liver transplantation as a recipient; or b) liver transplantation as a donor

Exclusion Criteria

• any absolute/relative contraindication of contrast-enhanced MRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Liver MRI	Liver MRI	In this study, MRI refers to phase-contrast 4D flow sequence.

Primary Outcome Measures

Name	Time	Method
Portal flow	in a month after 2nd MRI	portal flow measured with MRI (4D flow sequence)

Secondary Outcome Measures

Name	Time	Method
splenic varix flow	in a month after 2nd MRI	splenic varix flow measured with MRI (4D flow sequence) only in liver recipients
SMV flow	in a month after 2nd MRI	superior mesenteric vein (SMV) flow measured with MRI (4D flow sequence)
Splenic vein flow	in a month after 2nd MRI	splenic vein flow measured with MRI (4D flow sequence)

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of