Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery
- Conditions
- Chronic Sinusitis
- Interventions
- Registration Number
- NCT01569048
- Lead Sponsor
- Yonsei University
- Brief Summary
Various maneuvers are commonly used to achieve the ideal operative field necessary for successful endoscopic sinus surgery (ESS). Dexmedetomidine, a potent alpha2 adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response. And dexmedetomidine has an effect of peripheral vasoconstriction thus it is thus theologically appropriate for reducing bleeding during intranasal operation.
The aim of this study is to compare the effect of dexmedetomidine, an alpha2-adrenoreceptor agonist, on intraoperative bleeding, propofol requirement and postoperative profiles to remifentanil , an ultrashort-acting opioid.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 66
- ASA Ⅰ-Ⅱ
- Aged between 20 and 70 year
- General anesthesia for endoscopic sinus surgery
- Body mass index >30
- Congestive heart failure, Sinus Bradycardia(<50 BPM), Uncontrolled hypertension,
- Coagulopathy
- Drug addiction
- Pregnancy
- Allergic fungal infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description remifentanil propofol and remifentanil - dexmedetomidine Propofol and dexmedetomidine -
- Primary Outcome Measures
Name Time Method surgical satisfaction about visibility of operative field Within 1 day of endoscopic sinus surgery finish including dressing of surgical wound subjective satisfaction about visibility of operative field by surgeon/ numerous rating scale / 0: worst - 10:best
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Severance Hospital
🇰🇷Seoul, Korea, Republic of