Ammendment of protocol: Intravenous iron treatment in iron deficient patients with idiopathic pulmonary arterial hypertension. Title amendment: Skeletal muscle strength in healthy persons and patients with pulmonary hypertensio

Completed

• Conditions: high blood pressure in the lung vasculature; pulmonary hypertension; 10028302; 10037454; 10057166

• Registration Number: NL-OMON39402
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-03-01
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Idiopathic pulmonary arterial hypertension and iron deficiency
Amendment: Healthy controls

Exclusion Criteria

Current or recent iron treatment
Current other research treatment
Known history of anemia of other causes
Chronic (inflammatory) disease other than PAH
Amendment: Current or history of skeletal muscle problems and/or coagulation disturbances

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Six minute walking distance<br /><br><br /><br>Amendment: contractile force and structure of single quadriceps muscle fibers</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>cardiopulmonary exercise test (VO2max), myoglobin concentration in quadriceps<br /><br>muscle, serum iron parameters, serum hepcidin and interleukin-6 (IL-6), muscle<br /><br>strength, quality of life (QOL), and NYHA functional class, cardiac function<br /><br>(MRI).<br /><br><br /><br>Amendment: Submaximal CPET (75% Wmax)</p><br>