Green Coffee Extract Supplementation and Oxidative Stress, Systemic and Vascular Inflammation
Not Applicable
Completed
- Conditions
- Metabolic Syndrome
- Interventions
- Dietary Supplement: green coffee extract
- Registration Number
- NCT03265184
- Lead Sponsor
- National Nutrition and Food Technology Institute
- Brief Summary
Metabolic syndrome (Mets) is defined as the collection of risk factors contributing to type 2 diabetes mellitus and cardiovascular disease. Mets is accompanied by oxidative stress and low-grade inflammation. Green coffee is rich in polyphenols called chlorogenic acids (CGA) which possess anti-inflammatory and anti-oxidative characteristics. Thus, we carried out this trial to examine green coffee extract (GCE) effects on oxidative stress, systemic and vascular inflammation in patients having Mets
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
- body mass index of over 25, waist circumference >102 cm in men or >88 cm in women,Fasting blood glucose >100 mg/dL, Triglycerides (TG) > 150 mg/dL, High density lipoprotein cholesterol (HDL-C) <50 in women or <40 in men, Systolic blood pressure (SBP) >130 mmHg and diastolic blood pressure (DBP) >85mmHg
Exclusion Criteria
- insulin administration for diabetes control, having hypo- or hyperthyroidism, renal failure or other chronic diseases, regular coffee consumption, pregnancy, breastfeeding, taking estrogen, progesterone, corticosteroids, weight loss supplements and obeying unusual weight loss plans
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo group green coffee extract placebo capsules twice per day for 8 weeks have identical appearance to Green coffee extract capsules and contain starch intervention group green coffee extract 400 mg green coffee extract capsules twice per day for 8 weeks The Green coffee extract is standardised with 45% total chlorogenic acid by HPLC
- Primary Outcome Measures
Name Time Method intercellular adhesion molecule-1 (ICAM-1) 8 weeks interleukin-6 (IL-6) 8 weeks high sensitivity C-reactive protein (hs-CRP) 8 weeks malondialdehyde (MDA) 8 weeks
- Secondary Outcome Measures
Name Time Method