Periodization of Exercise Training in Patients With Coronary Heart Disease.

Not Applicable

Completed

• Conditions: Healthy Control; Coronary Heart Disease
• Interventions: Other: Exercise training

• Registration Number: NCT03443193
• Lead Sponsor: Montreal Heart Institute

Brief Summary

The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and after two different periodized training programs.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12-16
• Primary Completion: 2017-09-30
• Study First Submitted: 2018-01-22
• Study First Submitted QC: 2018-02-16
• Study First Posted: 2018-02-23
• Study Completion: 2021-12-31
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-29
• Last Update Posted: 2022-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Linear training	Exercise training	Linear training consists to a progressive improvement of the training load during the 3 month-program.
Non-linear training	Exercise training	Non-linear training consists to an undulating progressive improvement of the training load during the 3 month-program.

Primary Outcome Measures

Name	Time	Method
Maximal oxygen uptake (VO2peak) with gas exchange	At baseline and following 12 weeks exercise training intervention	VO2peak will be measured during maximal exercise test with a gas exchange device. The highest value reached during the exercise phase of the maximal test (ergocycle) will be considered as the VO2peak. We will measure change of VO2peak before and after exercise training.

Secondary Outcome Measures

Name	Time	Method
Standard echocardiographic parameter of left and right ventricular strain	At baseline and following 12 weeks exercise training intervention	global longitudinal strain (%) will be measued at rest for both ventricule
Cardiac hemodynamics	At baseline and following 12 weeks exercise training intervention	Cardiac hemodynamics will be measured continuously during the maximal exercise test on bike using an impedance cardiography device. We will measure change of cardiac hemodynamics before and after exercise training.
Cerebral hemodynamics	At baseline and following 12 weeks exercise training intervention	Cerebral hemodynamics will be measured using near-infrared spectroscopy (NIRS) system during maximal and submaximal exercise tests. We will measure change of cerebral hemodynamics before and after exercise training
Cognitive functions at rest by a by standard pen-paper battery test	At baseline and following 12 weeks exercise training intervention	Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. We will measure change of score to the cognitive tests before and after exercise training.

Trial Locations

Locations (1)

Cardiovascular prevention and rehabilitation center; 🇨🇦 Montréal, Quebec, Canada