NCT03443193已完成不适用
The Effects of Periodization Training on Physiological Parameters, Cerebral Oxygenation, Cognitive Functions and Cardiac Remodelling in Coronary Patients.
Montreal Heart Institute2 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2015年12月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Maximal oxygen uptake (VO2peak) with gas exchange
研究概览
简要总结
The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and after two different periodized training programs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for patients with coronary heart disease:
- •Adequate physical and mental capacities
- •Autonomy in daily activities
- •Documented coronary artery disease
- •Stable or recent coronary artery disease
排除标准
- •for patients with coronary heart disease:
- •Inability to complete the consent form
- •Acute coronary syndrome < 3 months
- •Heart failure
- •Ejection fraction of the left ventricle <40%
- •Coronary artery disease non revascularisable including left main coronary stenosis
- •Waiting for a bridging of the coronary artery
- •Chronic atrial fibrillation
- •Malignant arrhythmias during exercise
- •Restriction to non cardiopulmonary exercise
- •Severe intolerance to exercise
结局指标
主要结局
Maximal oxygen uptake (VO2peak) with gas exchange
时间窗: At baseline and following 12 weeks exercise training intervention
VO2peak will be measured during maximal exercise test with a gas exchange device. The highest value reached during the exercise phase of the maximal test (ergocycle) will be considered as the VO2peak. We will measure change of VO2peak before and after exercise training.
次要结局
- Standard echocardiographic parameter of left and right ventricular strain(At baseline and following 12 weeks exercise training intervention)
- Cardiac hemodynamics(At baseline and following 12 weeks exercise training intervention)
- Cerebral hemodynamics(At baseline and following 12 weeks exercise training intervention)
- Cognitive functions at rest by a by standard pen-paper battery test(At baseline and following 12 weeks exercise training intervention)
研究者
研究点 (2)
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