The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease

Not Applicable

Completed

• Conditions: COPD; Exercise; Resistance Training

• Registration Number: NCT02050945
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that:

Resistance training is superior to endurance training in patients with COPD

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-01-27
• Study First Submitted QC: 2014-01-29
• Study First Posted: 2014-01-31
• Primary Completion: 2015-03
• Study Completion: 2015-03
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-19
• Last Update Posted: 2015-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• FEV1/FVC fixed ratio <0.70, FEV1: <60% of predicted and MRC > or equal to 3
• Arterial oxygen saturation at rest> 90%, BMI >18, LVEF> 45.
• Age: 40 - 80 years

The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.

Exclusion Criteria

• Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Skeletal muscle function	At baseline and after 8 weeks of traning	Muscle biopsy

Secondary Outcome Measures

Name	Time	Method
Flow mediated dilation	Change from baseline at 8 weeks	Endothelium function
Body composition	Change from baseline at 8 weeks	DEXA scan
6 min walking test	Change from baseline at 8 weeks
Health Related Quality of Life - COPD assessment test (CAT)	Change from baseline at 8 weeks

Trial Locations

Locations (2)

Centre of Physical Activity Resarch; 🇩🇰 Copenhagen, Capital Region, Denmark

Centre of Physical Activity Research; 🇩🇰 Copenhagen, Capital Region, Denmark