The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Skeletal muscle function
研究概览
简要总结
The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that:
Resistance training is superior to endurance training in patients with COPD
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •FEV1/FVC fixed ratio <0.70, FEV1: <60% of predicted and MRC > or equal to 3
- •Arterial oxygen saturation at rest> 90%, BMI >18, LVEF>
- •Age: 40 - 80 years
- •The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.
排除标准
- •Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.
结局指标
主要结局
Skeletal muscle function
时间窗: At baseline and after 8 weeks of traning
Muscle biopsy
次要结局
- Flow mediated dilation(Change from baseline at 8 weeks)
- Body composition(Change from baseline at 8 weeks)
- 6 min walking test(Change from baseline at 8 weeks)
- Health Related Quality of Life - COPD assessment test (CAT)(Change from baseline at 8 weeks)
研究者
Anders Rasmussen Rinnov
Administrator
Rigshospitalet, Denmark