Comparison of Different Training Programs on Cognitive Function

Not Applicable

• Conditions: Mild Cognitive Impairment (MCI)

• Registration Number: NCT06682741
• Lead Sponsor: Poznan University of Physical Education

Brief Summary

The goal of the project is to identify the most effective exercise modalities in terms of neuroprotective effects and FP improvement.

Hypothesis: Dancing will increase BDNF, GDNF and CLU levels to a greater extent than traditional forms of AF, resulting in significantly greater improvements in FP in subjects aged ≥ 60 years. The study will involve 60 women aged ≥ 60 years, randomly and equitably assigned to training groups (i.e., resistance training using body weight, dance) and a control group (i.e., a group of physically inactive women).

Methodology:

Participants: 60 women aged ≥ 60 randomly and equally assigned to training groups (Dance and Resistance training) and a control group (i.e., physically inactive women)

Scientists will compare the impact of different forms of physical activity on cognitive functions

Detailed Description

The training interventions will last 6 months. The intensity of physical activity will be determined as a percentage of maximum heart rate (HRmax), assessed based on a fitness test (Chester Step Test), using data from mobile devices monitoring physical activity. Cognitive function (CF) levels, and the concentrations of GDNF, BDNF, and CLU, as well as the Chester Step Test, will be evaluated twice: once at baseline and once after the training programs. Blood samples for measuring neurotrophin and CLU levels will be collected in the morning, after an overnight fast (approximately 12 hours since the last meal). The concentrations of neurotrophins and CLU will be measured using the ELISA method. CF will be assessed using standardized and validated neuropsychological tests.

Expected Outcomes: Greater improvement in CF in the dance group compared to the resistance training and control groups, with higher levels of BDNF, GDNF, and CLU in the dance group.

Study Timeline

• Status Verified: 2024-09
• Study Start: 2024-09-17
• Study First Submitted: 2024-09-18
• Study First Submitted QC: 2024-11-08
• Last Update Submitted: 2024-11-08
• Study First Posted: 2024-11-11
• Last Update Posted: 2024-11-11
• Primary Completion: 2026-12-31
• Study Completion: 2027-06-30

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

• women

Exclusion Criteria

• previous diagnoses of cardiovascular diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
tle level of cognitive functions	before and after 12 months of interventions	Cognitive functioning is assessed using the standardized MoCA test, which has a maximum score of 30 points. A score of 26 or higher is considered normal

Secondary Outcome Measures

Name	Time	Method
blood markers	before and after 12 months of intervention	Neurotrophins, such as BDNF (Brain-Derived Neurotrophic Factor) and GDNF (Glial-Derived Neurotrophic Factor), as well as clusterin are measured from blood using an ELISA test kit

Trial Locations

Locations (1)

Poznan University of Physical Education; 🇵🇱 Poznan, Poland