Effect of Exercise Training in Alzheimer's Patients

Not Applicable

Completed

• Conditions: Alzheimer Disease
• Interventions: Other: Physical training

• Registration Number: NCT03981159
• Lead Sponsor: University of Genova

Brief Summary

The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.

Detailed Description

Alzheimer's disease is a neurodegenerative disease characterized by progressive and irreversible degeneration of nerve cells. The loss of these cells leads to the continuous decline in muscle function with alterations in biochemical and haematological parameters. The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-03-01
• Primary Completion: 2017-07-01
• Study Completion: 2017-11-15
• Study First Submitted: 2019-03-03
• Status Verified: 2019-06
• Study First Submitted QC: 2019-06-07
• Last Update Submitted: 2019-06-07
• Study First Posted: 2019-06-10
• Last Update Posted: 2019-06-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Subjects with official diagnosis of Alzheimer's disease;
• Subjects with MMSE higher than12.

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Exclusion Criteria

• Subjects with MMSE below 12 (indicating severe dementia and impairment).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Active group (under physical training)	Physical training	Subjects belonging to this arm underwent physical training for three months, twice per week (60 minutes per session).

Primary Outcome Measures

Name	Time	Method
White blood cell count	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Hemoglobin	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Platelet count	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Hematocrit	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Triglycerides	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Cholesterol	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Total bilirubin	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
AST (aspartate aminotransferase)	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
ALT (alanine aminotransferase)	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Blood pressure	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Creatinine	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Urea	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Glucose	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Sodium	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Calcium	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Potassium	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays
Tinetti test	Approximately 10-15 minutes	The 3-likert test assesses balance and gait abilities with an individual sitting in an armless chair, rising up, staying standing, turning 360° and then sitting back down. Gait is scored over 12 and balance is scored over 16, totalling 28 points.
Berg Balance Scale	Approximately 20 minutes	The 14-item 5-likert (from 0 to 4) scale objectively determines a patient's balance ability during a series of predetermined tasks. Scores of each item are summed up: the total score ranges from 0 to 56. The lowest the score the lowest is the level of function, the highest the score the highest is the level of function.
6-minute walking test	6 minutes	This test is a sub-maximal exercise used to evaluate aerobic capacity and endurance.
Timed up and go test	Approximately 14 seconds	The test measures abilities of a patient initially in a seated position The patient is then asked to stand up up, walk 3 meters, turn around, walk back to the chair and sit down.
"Walking While Talking" test	Approximately 1 minute	This test is a dual-task test, consisting in walking while reciting the alphabet or alternate letters of the alphabet.
Red blood cell count	Approximately 10-15 minutes	Assessed with routine blood/biochemical assays

Trial Locations

Locations (1)

University of Genova; 🇮🇹 Genoa, Italy