Effect of Exercise Training on Biochemical and Gait/Balance Parameters in Alzheimer's Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- University of Genova
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- White blood cell count
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.
Detailed Description
Alzheimer's disease is a neurodegenerative disease characterized by progressive and irreversible degeneration of nerve cells. The loss of these cells leads to the continuous decline in muscle function with alterations in biochemical and haematological parameters. The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.
Investigators
Maamer Slimani
Principal Investigator
University of Genova
Eligibility Criteria
Inclusion Criteria
- •Subjects with official diagnosis of Alzheimer's disease;
- •Subjects with MMSE higher than12.
Exclusion Criteria
- •Subjects with MMSE below 12 (indicating severe dementia and impairment).
Outcomes
Primary Outcomes
White blood cell count
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Hemoglobin
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Platelet count
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Hematocrit
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Triglycerides
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Cholesterol
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Total bilirubin
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
AST (aspartate aminotransferase)
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
ALT (alanine aminotransferase)
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Blood pressure
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Creatinine
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Urea
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Glucose
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Sodium
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Calcium
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Potassium
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Tinetti test
Time Frame: Approximately 10-15 minutes
The 3-likert test assesses balance and gait abilities with an individual sitting in an armless chair, rising up, staying standing, turning 360° and then sitting back down. Gait is scored over 12 and balance is scored over 16, totalling 28 points.
Berg Balance Scale
Time Frame: Approximately 20 minutes
The 14-item 5-likert (from 0 to 4) scale objectively determines a patient's balance ability during a series of predetermined tasks. Scores of each item are summed up: the total score ranges from 0 to 56. The lowest the score the lowest is the level of function, the highest the score the highest is the level of function.
6-minute walking test
Time Frame: 6 minutes
This test is a sub-maximal exercise used to evaluate aerobic capacity and endurance.
Timed up and go test
Time Frame: Approximately 14 seconds
The test measures abilities of a patient initially in a seated position The patient is then asked to stand up up, walk 3 meters, turn around, walk back to the chair and sit down.
"Walking While Talking" test
Time Frame: Approximately 1 minute
This test is a dual-task test, consisting in walking while reciting the alphabet or alternate letters of the alphabet.
Red blood cell count
Time Frame: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays