Effect of Exercise Training on Biochemical and Gait/Balance Parameters in Alzheimer's Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- White blood cell count
研究概览
简要总结
The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.
详细描述
Alzheimer's disease is a neurodegenerative disease characterized by progressive and irreversible degeneration of nerve cells. The loss of these cells leads to the continuous decline in muscle function with alterations in biochemical and haematological parameters. The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 80 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with official diagnosis of Alzheimer's disease;
- •Subjects with MMSE higher than12.
排除标准
- •Subjects with MMSE below 12 (indicating severe dementia and impairment).
研究组 & 干预措施
Passive group (no physical training)
Subjects served as controls.
Active group (under physical training)
Subjects belonging to this arm underwent physical training for three months, twice per week (60 minutes per session).
干预措施: Physical training (Other)
结局指标
主要结局
White blood cell count
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Hemoglobin
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Platelet count
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Hematocrit
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Triglycerides
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Cholesterol
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Total bilirubin
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
AST (aspartate aminotransferase)
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
ALT (alanine aminotransferase)
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Blood pressure
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Creatinine
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Urea
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Glucose
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Sodium
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Calcium
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Potassium
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
Tinetti test
时间窗: Approximately 10-15 minutes
The 3-likert test assesses balance and gait abilities with an individual sitting in an armless chair, rising up, staying standing, turning 360° and then sitting back down. Gait is scored over 12 and balance is scored over 16, totalling 28 points.
Berg Balance Scale
时间窗: Approximately 20 minutes
The 14-item 5-likert (from 0 to 4) scale objectively determines a patient's balance ability during a series of predetermined tasks. Scores of each item are summed up: the total score ranges from 0 to 56. The lowest the score the lowest is the level of function, the highest the score the highest is the level of function.
6-minute walking test
时间窗: 6 minutes
This test is a sub-maximal exercise used to evaluate aerobic capacity and endurance.
Timed up and go test
时间窗: Approximately 14 seconds
The test measures abilities of a patient initially in a seated position The patient is then asked to stand up up, walk 3 meters, turn around, walk back to the chair and sit down.
"Walking While Talking" test
时间窗: Approximately 1 minute
This test is a dual-task test, consisting in walking while reciting the alphabet or alternate letters of the alphabet.
Red blood cell count
时间窗: Approximately 10-15 minutes
Assessed with routine blood/biochemical assays
次要结局
未报告次要终点
研究者
Maamer Slimani
Principal Investigator
University of Genova