The Effect of Two Different Fluids (Balanced Crystalloids and Isotonic Saline) on Blood Electrolytes in very sick childre
Not Applicable
- Conditions
- Health Condition 1: I998- Other disorder of circulatory system
- Registration Number
- CTRI/2020/11/029131
- Lead Sponsor
- Sir Gangaram Hospital New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Age 1month to 18 years patients
â??Requiring IV fluids bolus for hypo-perfusion and/or hypotension as per discretion of treating clinician at admission or within 48 hours of admission
â??Patients requiring IV maintenance fluids.
Exclusion Criteria
All the patients
â??With burns, following liver transplant surgery.
â??Preexisting electrolyte abnormality or requirement of dialysis.
â??Diabetic ketoacidosis.
â??Congenital or acquired cardiac disease.
â??Known acute or chronic renal disease.
â??On diuretics or carbonic anhydrase inhibitors
â??Admitted on vasoactive drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the occurrence of chloride disturbance and hyperchloremia with the use of balanced crystalloids versus isotonic saline as resuscitation and maintenance fluids in critically ill children admitted over period of 48 hours.Timepoint: 48 hour post admission
- Secondary Outcome Measures
Name Time Method 1.Sodium potassium disturbances. <br/ ><br>2.Acid-base disturbances <br/ ><br>3.The incidence of Acute renal injury in first 48 hours in PICU as defined by KDIGO criteria <br/ ><br>4.The need and duration of RRT during the hospital stay <br/ ><br>5.Proportion of patients treated with and duration of treatment with vasoactive drugs. <br/ ><br>6.Duration of mechanical ventilation <br/ ><br>7.Duration of PICU and hospital stay <br/ ><br>8.All- cause mortality during PICU and hospital stay. <br/ ><br>Timepoint: Till 48 hours after admission and till discharge from hospital.