Cognition and Exercise Training
- Conditions
- Chronic Heart FailureMetabolic SyndromeCoronary Heart Disease
- Interventions
- Other: high intensity interval training (HIIT)Other: moderate intensity continuous exercise training
- Registration Number
- NCT01906957
- Lead Sponsor
- Montreal Heart Institute
- Brief Summary
The aim of study is to investigate the impact of two different training modalities (high intensity interval training (HIIT) versus moderate intensity continuous exercise training (MICET) on cognitive performance, cerebral oxygenation, cardiac output and physical fitness in older healthy adults, patients with metabolic syndrome, coronary heart disease and heart failure. The investigators hypothesized that HIIT modality will lead to a larger improvement in physical fitness (i.e. VO2peak), cardiovascular parameters (cardiac output and stroke volume) and cognitive performance at rest and during submaximal exercise. The primary endpoint will be the improvement in cognitive performance.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 6
Not provided
- For healthy elderly subjects:
- age under 60 years
- lack of expressed written consent
- metabolic syndrome
- coronary heart disease
- chronic systolic heart failure
- resting left ventricular ejection fraction < 40 %
- symptomatic aortic stenosis
- chronic atrial fibrillation
- malignant exertional arrhythmias
- non-cardiopulmonary limitation to exercise (e.g: arthritis or claudication)
- severe exercise intolerance.
For patients with metabolic syndrome:
- lack of expressed written consent
- coronary heart disease
- chronic systolic heart failure
- resting left ventricular ejection fraction < 40 %
- symptomatic aortic stenosis
- chronic atrial fibrillation
- malignant exertional arrhythmias
- non-cardiopulmonary limitation to exercise (e.g: arthritis or claudication)
- severe exercise intolerance.
For patients with CHD
- lack of expressed written consent
- recent acute coronary event (< 3 months)
- chronic systolic heart failure
- resting left ventricular ejection fraction < 40 %
- symptomatic aortic stenosis
- severe non-revascularize coronary disease including left main coronary stenosis
- patient awaiting coronary artery bypass surgery
- chronic atrial fibrillation
- presence of permanent ventricular pacemaker
- malignant exertional arrhythmias
- non-cardiopulmonary limitation to exercise (e.g: arthritis or claudication)
- severe exercise intolerance.
For CHF patients:
- Any relative or absolute contraindications to exercise training among patients with stable chronic heart failure according to current recommendations (Working Group on Cardiac Rehabilitation 2001)
- Fixed-rate pacemaker or ICD devices with heart rate limits set lower than the exercise training target heart rate.
- Major cardiovascular event of procedure within the 3 months preceding enrolment in the study.
- Atrial fibrillation
- Heart failure secondary to significant uncorrected primary valvular disease (except for mitral regurgitation secondary to LV dysfunction)
- Heart failure secondary to congenital heart disease or obstructive cardiomyopathy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Elderly healthy subjects moderate intensity continuous exercise training Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) coronary patients high intensity interval training (HIIT) Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) coronary patients moderate intensity continuous exercise training Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) Elderly healthy subjects high intensity interval training (HIIT) Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) Patients with metabolic syndrome moderate intensity continuous exercise training Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) heart failure patients high intensity interval training (HIIT) Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) Patients with metabolic syndrome high intensity interval training (HIIT) Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20) heart failure patients moderate intensity continuous exercise training Randomization into : 1. high intensity interval training (HIIT)(n=20) or 2. moderate intensity intensity continuous exercise (n=20)
- Primary Outcome Measures
Name Time Method Cognitive function assessed by standard pen-paper battery test At baseline and after 3 months a) Digit Span (Forward and Backward) (short-term and working memory), b) Digit Symbol Substitution Test (attention \& processing speed), c) Trail making test, part A and B (mental flexibility), d) D-KEFS Color-Word Interference Stroop Test (selective attention and inhibition) and e) Rey Auditory Verbal Learning Test (long-term verbal memory).
- Secondary Outcome Measures
Name Time Method Maximal aerobic capacity (VO2max) At baseline and after 3 months Gas exchanges will be measured during maximal incremental test. The highest value reached during the exercise phase of the maximal test (ergocycle) will be considered as the VO2max.
Trial Locations
- Locations (2)
Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada
Cardiovascular Prevention and Rehabilitation Centre (EPIC), Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada