NCT00929136已完成不适用
The Effect of Regional Inflammation on Metabolism and Insulin Sensitivity in the Lower Extremity.
Aarhus University Hospital2 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2009年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- glucose concentration
研究概览
简要总结
The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Normal health
- •22 < BMI < 28
- •Written Informed Concent
排除标准
- •Any disease
- •Any use of medication
- •Recent immobilization of a lower extremity
结局指标
主要结局
glucose concentration
时间窗: 360 minutes observation
次要结局
- Regional arteriovenous amino-acid balance(measured at t=180 and 360 minutes)
- Intra-cellular insulin signaling(measured at t=0, 120, and, 210 minutes)
- Regional arteriovenous lipid balance(measured at t=180 and 360 minutes)
研究者
研究点 (2)
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