Metabolic Effects of Endotoxin Induced Acute Inflammation in Healthy Young Men With and Without Supplement of Amino Acids.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Protein catabolism during acute illness
研究概览
简要总结
The purpose of the study is to investigate the metabolic effects during acute inflammation with and without the nutritional supplement of amino acids.
E. Coli Endotoxin (LPS, lipopolysaccharide) is used to initiate an inflammatory response.
The study is an interventional randomized placebo study including 8 healthy male subjects. Each subject participates 3 times (different days) and are given one of following interventions:
- Placebo (NaCl)
- Endotoxin, US standard reference E.Coli + Placebo (NaCl)
- Endotoxin, US standard reference E.Coli + Amino acids (intravenously)
It is our hypothesis that the nutritional intervention during acute inflammation plays an important role in lipid and protein metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •male gender
- •20<BMI<30
- •Age > 25 years old
- •Written consent before starting the study
排除标准
- •Allergy for soya products ore egg
- •Infection
- •Immune defects
- •Heart disease
- •Dysregulated hypertension
- •Participating in other trials using radioactive tracers or x-rays the last year.
结局指标
主要结局
Protein catabolism during acute illness
时间窗: After 6 hours intervention
Protein catabolism is measured with amino acid tracer techniques comparing radioactive marked amino acids from blood samples.
次要结局
- Other systemic metabolic effects during acute illness(6 hours)
- The local effects on muscle and fat tissue(At 2 hours and 4,5 hours)
研究者
Nikolaj Fibiger Rittig
MD (medical graduate) and Ph.d.-student
University of Aarhus