A Comparison of Pain Severity on Injection of MCT/LCT Propofol Between Lidocaine 20 mg, 40 mg, and Without Lidocaine.
- Registration Number
- NCT01345981
- Lead Sponsor
- Prince of Songkla University
- Brief Summary
To compare the severity of pain on injection of MCT/LCT propofol with lidocaine 20 mg, 40 mg, and without lidocaine.
- Detailed Description
Background: Intravenous injection of propofol produces pain. Many factors are involved and various techniques have been tried to minimize the propofol-induce pain with variable results.
Objective: To compare the severity of pain on injection of MCT/LCT propofol with lidocaine 20 mg, 40 mg, and without lidocaine.
Design: Randomize controlled trial. Method: Two hundred and ten ASA class I - III patients undergoing elective surgery were blinded and equally allocated into 3 groups. Patients in group N, L1, and L2 received MCT/LCT propofol 10 ml mixed with 0.9% NaCl 2 ml, 1% lidocaine 2 ml, and 2% lidocaine 2 ml respectively. Pain at time of propofol injection was assessed by blinded anesthesiologist on a four point scale ; 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain. Results: Patient's demographic data of each group were similar. There were significant differences in the incidence of propofol injection without pain among groups (p\<0.001). The numbers of patients who had moderate and severe pain in groups L1 and L2 were significantly less than those in group N (p\<0.001). The mean blood pressure and heart rate were not significant differences in among groups. Conclusion : The amount of 20 mg, and 40 mg lidocaine to MCT/LCT propofol in our study is equally effective in decreasing pain and more effective than MCT/LCT propofol alone group significantly. They were no significant differences in hemodynamics change in among groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 210
- ASA class I - III patients
- undergoing elective surgery
- age 18-75 years
- allergy to propofol and lidocaine
- abnormal liver and renal functions
- has psychological problem or drug abuse
- has recieved analgesic drug 2 weeks prior to surgery
- risk of aspiration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description normal saline Lidocaine 2 ml lidocaine 20 mg Lidocaine intravenous lidocaine lidocaine 40 mg Lidocaine intravenous lidocaine 40 mg
- Primary Outcome Measures
Name Time Method pain on injection 30 minutes 4 points score for pain:o=no pain,1=mild pain,2=moderate pain,3=severe pain after propofol injection
- Secondary Outcome Measures
Name Time Method hemodynamic change 30 minutes blood pressure and heart rate after propofol injection
Trial Locations
- Locations (1)
Songklanagarind Hospital
🇹🇭Hatyai, Songkhla, Thailand