Effects of Two Doses of Thylakoids on OGTT
- Conditions
- Glucose Intolerance
- Registration Number
- NCT02702245
- Lead Sponsor
- Region Skane
- Brief Summary
This cross-over intervention study aims to investigate the effect of two doses of thylakoids to an oral glucose tolerance test (OGTT) on glucose and insulin homeostasis as well as appetite regulating hormones in healthy volunteers.
- Detailed Description
A minimum of twenty healthy volunteers are recruited to participate in an OGTT at three different occasions separated by one week. At two of the occasions a green leaf extract, thylakoids, is added to a glucose solution; 5 gram or 10 gram in randomized order. The third occasion, without added thylakoids, serve as control.
Blood samples are taken fasting and 15, 30, 45, 60, 90, 120 and 180 minutes after the glucose load.
Blood samples are analysed for p-glucose, p-insulin, p-C-peptide, p-ghrelin, p-CCK and p-GLP-1.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
- Healthy
- Adult
- Normal-weight and weight stable
- Not pregnant or breast-feeding
- No use of medication that can affect glucose- and insulin homeostasis (for example corticosteroids).
- Diabetes,
- Impaired glucose tolerance and/or insulin resistance
- Anaemia
- Use of tobacco or drugs.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Insulin sensitivity 180 minutes, repeated at three occasions Measurement of p-glucose, p-insulin and p-C-peptide in repeated blood sampling during three hours after an OGTT.
- Secondary Outcome Measures
Name Time Method p-GLP-1 180 minutes, repeated at three occasions Repeated blood sampling during three hours after an OGTT.
p-ghrelin 180 minutes, repeated at three occasions Repeated blood sampling during three hours after an OGTT.