The Effect of Positive End-expiratory Pressure During Induction of General Anesthesia and Non-hypoxic Apnea Time in Infants: a Randomized Controlled Trials
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- apnea time
Study Overview
Brief Summary
Invesetigators evaluated the effect of positive end-expiratory pressure during anaesthesia induction on nonhypoxic apnoea time in infants. Invesetigators assigned infants to a 7 cmH2O positive end expiratory pressure (PEEP) with fraction of inspired oxygen 80% or 0 cmH2O PEEP with fraction of oxygen 80% group. Anaesthesia was induced with 0.02 mg kg atropine, 5 mg kg thiopental sodium and 3 to 5% sevoflurane, and neuromuscular blockade with 0.6 mg kg rocuronium. Thereafter, 80% oxygen was provided via face mask with volume-controlled ventilation of 6 ml kg tidal volume, and either 7 cmH2O or no positive end-expiratory pressure. After 3 min of ventilation, the infants' trachea was intubated but disconnected from the breathing circuit, and ventilation resumed when pulse oximetry reached 95%.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 1 Month to 12 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •We included paediatric patients aged 12 months or less about to receive general anaesthesia with endotracheal intubation.
Exclusion Criteria
- •Neonates, former preterm infants with gestational age less than 60 weeks at the day of surgery, with previous history of respiratory disease, those with anticipated difficult mask ventilation or intubation and those with upper respiratory infection within 3 weeks were excluded.
Arms & Interventions
fraction of inspired oxygen 80%
Intervention: fraction of inspired oxygen 80% (Other)
Fraction of inspired oxygen 80% with positive end expiratory pressure
Intervention: positive end expiratory pressure (Other)
Outcomes
Primary Outcomes
apnea time
Time Frame: during face mask ventilation, maximum 3 minutes.
The primary outcome was nonhypoxic apnoea time defined as the time from cessation of ventilation to a pulse oximeter reading of 95%
Secondary Outcomes
- atelectasis score (0~72)(during anesthesia induction, maximum 5 minutes.)
- Number of participants with gastric air insufflation(during anesthesia induction, maximum 5 minutes.)
Investigators
Hee-Soo Kim
professor
Seoul National University Hospital