DRKS00030889RecruitingUnknown
Influence of extracorporeal circulation on perioperative cefuroxime concentrations in bypass surgery patients.Exploratory, prospective, open-label, monocentric study to investigate the influence of operative extracorporeal circulation on perioperative cefuroxime concentrations using microdialysis technique in bypass surgery patients
niversitätsklinikum Augsburg0 sites30 target enrollmentStarted: June 27, 2023Last updated:
Conditions
Trial Snapshot
- Phase
- Unknown
- Status
- Recruiting
- Sponsor
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized controlled study
- Masking
- Open (masking not used)
Eligibility Criteria
- Ages
- 18 Years to one (—)
- Sex
- All
Inclusion Criteria
- •Patients undergoing elective bypass surgery who require perioperative antibiotic prophylaxis
- •- Written declaration of consent by the patient
Exclusion Criteria
- •- Patients who have received therapy with cefuroxime in the 72 hours prior to surgery.
- •- Known allergic reaction, hypersensitivity or contraindication to cefuroxime or other ß-lactam antibiotics (e.g. penicillins, cephalosporins).
- •- Severe renal insufficiency < 20 ml/min/1.73 m2
- •- Non-guideline discontinuation of blood thinning medications
- •Medications if urgency does not allow the surgery to be postponed for the appropriate number of days.
- •- Active participation in other interventional studies according to AMG or MPDG
- •- Women during pregnancy or breastfeeding
Investigators
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