Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery
Completed
- Conditions
- Acquired Platelet Function Disorder
- Registration Number
- NCT01354847
- Lead Sponsor
- Goethe University
- Brief Summary
This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.
- Detailed Description
Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function.
Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- duration of extracorporeal circulation > 120 min
Exclusion Criteria
- pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation) Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU Multiple Electrode aggregometry parameters
- Secondary Outcome Measures
Name Time Method Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation) Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU Multiple electrode aggregometry analyses
Trial Locations
- Locations (1)
Goethe - University
🇩🇪Frankfurt, Hessen, Germany
Goethe - University🇩🇪Frankfurt, Hessen, Germany