Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery

Completed

• Conditions: Acquired Platelet Function Disorder
• Interventions: Device: Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)

• Registration Number: NCT01354847
• Lead Sponsor: Goethe University

Brief Summary

This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.

Detailed Description

Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function.

Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.

Study Timeline

• Study First Submitted: 2011-05-02
• Study First Submitted QC: 2011-05-16
• Study First Posted: 2011-05-17
• Study Start: 2011-06
• Status Verified: 2013-10
• Primary Completion: 2013-10
• Study Completion: 2013-10
• Last Update Submitted: 2013-10-25
• Last Update Posted: 2013-10-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• duration of extracorporeal circulation > 120 min

Exclusion Criteria

• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cardiac surgery patients	Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)	cardiac surgery patients scheduled for elective complex cardiac surgery

Primary Outcome Measures

Name	Time	Method
Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation)	Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU	Multiple Electrode aggregometry parameters

Secondary Outcome Measures

Name	Time	Method
Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation)	Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU	Multiple electrode aggregometry analyses

Trial Locations

Locations (1)

Goethe - University; 🇩🇪 Frankfurt, Hessen, Germany