Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Extracorporeal Membrane Oxygenation
- Sponsor
- Aarhus University Hospital
- Enrollment
- 33
- Locations
- 2
- Primary Endpoint
- Changes in platelet function
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding of the mechanisms underlying their coagulopathy.
The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).
Detailed Description
The knowledge of platelet function during extracorporeal membrane oxygenation (ECMO) remains sparse. In the present study, the aim is to investigate platelet function in adult patients treated with ECMO using flow cytometry. The investigators hypothesize that platelet function increases from day 1 to day 3 in patients treated with ECMO. The secondary aim is to investigate the association between platelet function and the incidence of bleeding episodes and thrombosis during ECMO treatment. The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Treatment with veno-venous or veno-arterial ECMO
- •Age ≥18 years
Exclusion Criteria
- •ECMO treatment initiated post-operatively
Outcomes
Primary Outcomes
Changes in platelet function
Time Frame: Platelet function measured day 1 and day 3 on ECMO
Platelet function on day 3 compared with day 1 on ECMO. Measured by flow cytometry
Secondary Outcomes
- Changes in platelet aggregation(Platelet function measured every morning from day 1 to day 8 on ECMO (except weekends).)
- Immature platelet count(Measured every morning from day 1 to day 8 on ECMO (except weekends))
- Platelet count(Measured every morning from day 1 to day 8 on ECMO (except weekends))