The Association Between Nutritional Status and Muscle Wasting and Fraility in Intensive Care Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Changes in muscle cross-sectional area
研究概览
简要总结
The risk of muscle wasting is high in the intensive care unit patients during the treatment process and this condition is associated with adverse clinical outcomes. The etiology of muscle wasting is multifactorial and medical nutrition therapy plays a key role in muscle wasting treatment and prevention. The aim of this study is assesing the malnutrition and fraility, anthropometric measurements, and muscle mass by ultrasound at the first admission to the intensive care unit and to determine the nutritional factors affecting clinical outcomes. In addition, it is planned to determine the risk factors affecting the change of anthropometric measurements and muscle wasting in the first week during the intensive care unit.
详细描述
A nutrition-focused physical examination is an integral component in the assessment of critically ill patients. Malnutrition, muscle wasting, and frailty are multidimensional clinical conditions in critically ill patients and are associated with adverse outcomes. Although malnutrition, muscle wasting and frailty are linked, the exact relation between them is unsure. As a result of evaluating these conditions together, it is planned to develop new treatment strategies and to improve the clinical results of patients by determining the relationship between medical nutrition therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥45 years and ≤80 years, male or female
- •Expected ICU stay of seven days or longer
- •Written informed consent or requirements of local/national ethical committee
排除标准
- •Pregnancy or breastfeeding
- •Neuromuscular conditions (e.g., multiple sclerosis, muscular dystrophy, spinal cord injury, Guillain-Barre syndrome)
- •Terminal cancer
- •Dialysis dependent chronic renal failure
- •Intoxication
- •Burn injury
- •A cognitive impairment prior to the acute illness that is associated with admission to ICU that would impair capacity to follow verbal instructions
- •Concurrent enrolment in a nutrition-related interventional study at the time of screening
结局指标
主要结局
Changes in muscle cross-sectional area
时间窗: Baseline and 7 days
Rectus femoris muscle cross-sectional area will be evaluated by ultrasound.
Changes in anthropometric measurements
时间窗: Baseline and 7 days
Triceps skinfold thickness will be measured by caliper.
次要结局
- Duration of mechanical ventilation(Time of admission to the ICU until the time of discharge from the intensive care unit, up to 1 year)
- Mortality rate(Time of admission to the ICU until the time of discharge from the intensive care unit, up to 1 year)
研究者
Melda Kangalgil
Research Assistant
Karadeniz Technical University