:â??COMPARISON OF PROPOFOL REQUIREMENT DURING THREE PHASES OF LIVER TRANSPLANT SURGERYâ??
Not Applicable
- Conditions
- Health Condition 1: K74- Fibrosis and cirrhosis of liver
- Registration Number
- CTRI/2023/01/049206
- Lead Sponsor
- DR YATIN KALRA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients diagnosed with CLD posted for Liver Transplant Surgery
Exclusion Criteria
1. Patient denying consent
2. Known allergy to eggs or propofol
3. Requirement for pretransplant mechanical ventilation
4. Use of vasopressors prior to transplantation.
5. Any modification in anaesthesia treating protocol
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the mean target concentration of propofol required to maintain BIS between 40-60 during the three phases of Liver Transplant SurgeryTimepoint: At the end of Dissection Phase - time of portal vein clamping during surgery <br/ ><br> <br/ ><br>At the end of Anhepatic Phase - At the time of portal vein unclamping during surgery <br/ ><br> <br/ ><br>At the end of Neohepatic Phase - Time of last skin suture during closure of abdomen <br/ ><br> <br/ ><br>of the liver transplant surgery
- Secondary Outcome Measures
Name Time Method To compare the total requirement of propofol in each of the three phases of Liver Transplant Surgery in pts with MELD 15-20, 20-25, more than 25Timepoint: End of Dissection Phase - At the time of portal vein clamping during surgery <br/ ><br> <br/ ><br>End of Anhepatic Phase - Time of portal vein unclamping during surgery <br/ ><br> <br/ ><br>End of Neohepatic Phase - Time of last skin suture during closure of abdomen;To compare the overall total requirement of propofol in pts with MELD 15-20, 20-25, more than 25Timepoint: Time of last skin suture during closure of abdomen