Vitamin D and chronic urticaria
- Conditions
- Vitamin D deficient Chronic Urticaria
- Registration Number
- CTRI/2017/02/007871
- Lead Sponsor
- JIPMER
- Brief Summary
The purpose of this study is to asess the effect of vitamin D on clinical outcomes and on the changes in levels of 25-hydroxy vitamin D, vitamin D binding protein, hs-CRP ,TGF-β, IL-17, IL-6 and also to study its effect on medication use in Chronic Urticaria patients with vitamin D deficiency. We hypothesize that vitamin D deficient Chronic Urticaria patients receiving vitamin D would have a better clinical outcome and less disease severity when compared to those receiving placebo. Hence vitamin D would improve the quality of life of Chronic Urticaria patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- All
- Target Recruitment
- 120
Age and gender matched consenting patients with Chronic urticaria (presence of continuous or recurrent hives with or without angioedema for greater than 6 weeks duration) with vitamin D deficiency (serum vitamin D less than 20 ng per ml) attending the Dermatology Clinic in JIPMER during the study period.
Patients with •Acute urticaria/physical urticaria/urticarial vasculitis •Hereditary or acquired angioedema •Symptoms of vitamin D deficiency such as musculoskeletal pain, fractures •Patients with hepatic or renal dysfunction •Malignancies/ Infections •Inflammatory cutaneous disorders (psoriasis, lichen planus, pityriasis rubra pilaris, erythroderma, allergic contact dermatitis) •Pregnant and lactating women will be excluded from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the effect of Vitamin D on clinical outcome by USS(Urticaria Severity Score) Baseline, 6 and 12 weeks
- Secondary Outcome Measures
Name Time Method To assess the changes in levels of 25-hydroxy vitamin D, vitamin D binding protein, hs-CRP ,TGF-β, IL-17, IL-6. Baseline and 12 weeks
Trial Locations
- Locations (1)
JIPMER
🇮🇳Pondicherry, PONDICHERRY, India
JIPMER🇮🇳Pondicherry, PONDICHERRY, IndiaDr Archana MPrincipal investigator9751799269archujp15@gmail.com