The Role of Narrow Band Imaging Videobronchoscopy in Lung Cancer

Completed

• Conditions: Lung Cancer

• Registration Number: NCT01178190
• Lead Sponsor: Asan Medical Center

Brief Summary

Narrow band imaging (NBI) videobronchoscopy is an optical technique in which filtered light enhances superficial neoplasm based on their neoangiogenic pattern. The objectives of this study investigate its better diagnostic yield in the assessment of lung cancer than conventional flexible bronchoscopy.

Detailed Description

Inspection with high resolution endoscopy was followed by NBI. Detected lesions were biopsied. applied the system of shibuya et al. to analyze and classify vascular patterns by NBI into four categories (spiral and screw pattern, dotted pattern, tortuous pattern, avascular pattern) compared with the known diagnostic yield of conventional white light bronchoscopy, An equivalent or superior result will also significantly impact on patient care This technology could aid not only early-stage lung cancer diagnosis but also more accurate local staging of lung cancer.

Study Timeline

• Study Start: 2009-07
• Status Verified: 2010-06
• Primary Completion: 2010-06
• Study Completion: 2010-06
• Study First Submitted: 2010-07-28
• Study First Submitted QC: 2010-08-09
• Last Update Submitted: 2010-08-09
• Study First Posted: 2010-08-10
• Last Update Posted: 2010-08-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• endobronchial lesion on chest CT

Exclusion Criteria

• Age < 18 years old
• Inability to consent for the study
• Inability to tolerate bronchoscopy
• Active pulmonary infection (bronchitis, pneumonia)
• ST elevation or depression on ECG
• Prothrombin time prolongation(<70%)
• platelet <10,000

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
accuracy of NBI videobronchoscopic biopsy	10-11 months	Define and compare the sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio and accuriacies for the diagnostic techniques for lung cancer.

Secondary Outcome Measures

Name	Time	Method
early cancer lesion detection rate using Shibuya descriptors	10-11 months	Define and compare the sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio and accuriacies for the diagnostic techniques for early lung cancer.

Trial Locations

Locations (1)

ChangMin, Choi; 🇰🇷 Seoul, Korea, Republic of