Hs- Troponin I, as a predictive marker of cardiovascular instability in sepsis and septic shock- A prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To measure and determine, Hs-Troponin I level, as a predictive marker of transformation of sepsis into sepsis induced cardiac dysfunction/septic shock in critically ill patients.
研究概览
简要总结
Sepsis often triggers a systemic inflammatory response that can lead to cardiovascular dysfunction, affecting the heart’s ability to pump blood effectively. The heart may experience stress and injury during the progression of sepsis. In situations of cardiac stress or injury, such as during sepsis, troponin I can be released into the bloodstream.
•Highly sensitive troponin I (Hs-Tn I) refers to a more advanced and precise assay used to measure troponin I levels in the blood. They provide increased sensitivity, improved specificity, lower detection limit, better monitoring, rapid diagnosis and improved risk stratification.
•Increased Hs-troponin I levels in sepsis patients may be associated with a higher likelihood of progression to septic shock. The biomarker provides valuable prognostic information, aiding clinicians in assessing the severity of cardiovascular involvement and predicting the risk of deteriorating into a critical state. Early recognition of cardiac involvement may prompt interventions aimed at preventing or mitigating the progression to septic shock.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •End stage Renal disease with sepsis.
- •Requiring vasopressors and ionotropes.
排除标准
- •1.Age less than 18 years 2.Acute coronary syndrome 3.Myocardial injury, Post cardiac surgery patients 4.Posted for any surgical procedures 5.Immunological disorders 6.Pregnant women.
结局指标
主要结局
To measure and determine, Hs-Troponin I level, as a predictive marker of transformation of sepsis into sepsis induced cardiac dysfunction/septic shock in critically ill patients.
时间窗: 1.upon admission | 2.at 24 hours of admission | 3.at the onset of cardiovascular instability
次要结局
- To follow up the 2D ECHO findings for early recognition and intervention to mitigate the progression into septic shock.(1.upon admission)
研究者
Dr Damerla V N L Prathyusha
MEDICOVER Hospitals