Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake
- Conditions
- Obesity
- Interventions
- Behavioral: Physical activity
- Registration Number
- NCT01824680
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program. Hormones assessed are: leptin, grhélin, Cholecystokinin, Glucagon-Like-Peptid-1 (GLP-1), PYY.
It is well known that in overweight adults and children also, an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program.
Our hypothesis are: a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program, an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program, a diminution of the level of GLP-1 and leptin before and after the physical activity program
- Detailed Description
There is two sequences, one before and one after the physical activity program. Each sequence contains one "rest" session and one "exercise" session.
Each session contains : blood sample at regular interval (Leptin, Ghrélin, CCK, PYY, GLP-1), a sleeping assessment (Pittsburg scale), an assessment of hunger sensations at regular interval, an assessment of food intake in a "ad libitum" lunch and in the diner indirectly by the SU.VI.MAX. tool.
During the " rest " session :
Blood samples, assessment of hunger sensation, assessment of food intake are realized during the morning. Physical condition (VO2 max, DEXA, and muscular test), insulin-sensibility, lipid profile, are also assessed.
During the "exercise" session: it is identical to the first session but an intense exercise of 40 minutes is realized at 70% of the patient's VO2 max. The peripherical blood output is measured by a non-invasive method: the Near-Infra-Red-Spectroscopy, during the exercise.
The 3-months-physical activity program : there is 4 sessions of 30 minutes and 2 sessions of 1 hour per week. Most of exercises sessions are realized at home but one 1-hour session per week is controled with a sports educator.
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 30
Overweight adolescents (over the 90 th percentile of the international cut-off point)
- With a computer and an internet connection
- Sedentary (according to the IPAQ-A questionnaire)
- Without eating disorders (according to the DEBQ questionnaire)
- Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease.
- Drugs that could interfere with the results of the study
- Surgical intervention in the 3 months
- Regular consumption of tobacco or Alcohol
- patients on a diet with caloric restriction
- Refusal to sign the consent form
- Regular practice of sport and intensive
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description obesity Physical activity -
- Primary Outcome Measures
Name Time Method Comparison before and after the physical activity program of the effect of intense exercise on kinetic of secretion of regulation hormones: Leptin, Grhélin, CCK, PYY3-36, GLP-1 after 3 months of physical activity
- Secondary Outcome Measures
Name Time Method Comparison, before and after the physical activity program, of Hunger sensation by Visual Analogic Scales after 3 months of physical activity Comparison, before and after the physical activity program of food intake after 3 months of physical activity Comparison, before and after the physical activity program of insulinosensibility after 3 months of physical activity Comparison, before and after the physical activity program of peripheral blood output after 3 months of physical activity Comparison, before and after the physical activity program of sleep quality agter 3 months of physical activity Comparison, before and after the physical activity program of physical condition after 3 months of physical activity
Trial Locations
- Locations (1)
CHU Clermont-Ferrand
🇫🇷Clermont-Ferrand, France