Effect of a 3 Months Physical Activity Program on the Hormonal Regulation of Food Intake by Intense Physical Activity in Overweight Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Comparison before and after the physical activity program of the effect of intense exercise on kinetic of secretion of regulation hormones: Leptin, Grhélin, CCK, PYY3-36, GLP-1
研究概览
简要总结
The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program. Hormones assessed are: leptin, grhélin, Cholecystokinin, Glucagon-Like-Peptid-1 (GLP-1), PYY.
It is well known that in overweight adults and children also, an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program.
Our hypothesis are: a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program, an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program, a diminution of the level of GLP-1 and leptin before and after the physical activity program
详细描述
There is two sequences, one before and one after the physical activity program. Each sequence contains one "rest" session and one "exercise" session.
Each session contains : blood sample at regular interval (Leptin, Ghrélin, CCK, PYY, GLP-1), a sleeping assessment (Pittsburg scale), an assessment of hunger sensations at regular interval, an assessment of food intake in a "ad libitum" lunch and in the diner indirectly by the SU.VI.MAX. tool.
During the " rest " session :
Blood samples, assessment of hunger sensation, assessment of food intake are realized during the morning. Physical condition (VO2 max, DEXA, and muscular test), insulin-sensibility, lipid profile, are also assessed.
During the "exercise" session: it is identical to the first session but an intense exercise of 40 minutes is realized at 70% of the patient's VO2 max. The peripherical blood output is measured by a non-invasive method: the Near-Infra-Red-Spectroscopy, during the exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Overweight adolescents (over the 90 th percentile of the international cut-off point)
- •With a computer and an internet connection
- •Sedentary (according to the IPAQ-A questionnaire)
- •Without eating disorders (according to the DEBQ questionnaire)
排除标准
- •Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease.
- •Drugs that could interfere with the results of the study
- •Surgical intervention in the 3 months
- •Regular consumption of tobacco or Alcohol
- •patients on a diet with caloric restriction
- •Refusal to sign the consent form
- •Regular practice of sport and intensive
结局指标
主要结局
Comparison before and after the physical activity program of the effect of intense exercise on kinetic of secretion of regulation hormones: Leptin, Grhélin, CCK, PYY3-36, GLP-1
时间窗: after 3 months of physical activity
次要结局
- Comparison, before and after the physical activity program, of Hunger sensation by Visual Analogic Scales(after 3 months of physical activity)
- Comparison, before and after the physical activity program of food intake(after 3 months of physical activity)
- Comparison, before and after the physical activity program of insulinosensibility(after 3 months of physical activity)
- Comparison, before and after the physical activity program of peripheral blood output(after 3 months of physical activity)
- Comparison, before and after the physical activity program of sleep quality(agter 3 months of physical activity)
- Comparison, before and after the physical activity program of physical condition(after 3 months of physical activity)