Liver Status in Psychiatric Inpatients

Not Applicable

Completed

• Conditions: Psychiatric Illness
• Interventions: Diagnostic Test: To estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease.

• Registration Number: NCT05213442
• Lead Sponsor: Hôpital le Vinatier

Brief Summary

Adults hospitalized in psychiatry have an increased frequency of somatic disorders, in particular various liver diseases (viral hepatitis, non-alcohol related liver steatosis, alcohol related liver disease).

The evaluation of these liver disorders in psychiatric inpatients remains very little explored in France, contributing to the poor overall medical status of psychiatric patients.

The LIVERSPIN study aims to estimate the prevalence rates of liver pathologies in psychiatric inpatients and to explore the factors associated with the existence of a liver pathology

Detailed Description

The LIVERSPIN study aims to estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease.

All hospitalized patients can potentially be recruited. They will benefit from the usual clinical and paraclinical examinations as part of their hospitalization diagnostic work-up. For the determination of biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination.

Study Timeline

• Study First Submitted: 2022-01-26
• Study First Submitted QC: 2022-01-26
• Study First Posted: 2022-01-28
• Study Start: 2022-04-06
• Primary Completion: 2023-12-15
• Study Completion: 2023-12-15
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-13
• Last Update Posted: 2024-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

• Age >18 years old
• Social insurance
• Current hospitalization in any psychiatric unit of the participating center
• Adult or legal representative who has given written and informed consent to participate in the study. By default, the oral consent of the adult will be obtained (as well as the written consent of the legal representative)
• Information given to the curator(for people under curatorship)

Exclusion Criteria

• • Clinical state of the patient which do not allow the collection of study data (according to the investigator)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
All inpatients in Vinatier psychiatric Hospital	To estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease.	All hospitalized patients can potentially be recruited. They will benefit from the usual clinical and paraclinical examinations as part of their hospitalization diagnostic work-up. For the determination of biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination.

Primary Outcome Measures

Name	Time	Method
HCV diagnosis	At inclusion	HCV diagnosis defined by positive HCV antibodies in blood

Secondary Outcome Measures

Name	Time	Method
HBV diagnosis	At inclusion	HBV diagnosis defined by positive HBsAg in blood
HIV diagnosis	At inclusion	HIV diagnosis defined by positive anti-HIV1 or anti-HIV2 antibodies in blood
Suspicion of NAFLD	At inclusion	Suspicion of NAFLD on FIB-4 and the interrogation
Suspicion of alcoholic liver disease	At inclusion	Suspicion of alcoholic liver disease on FIB-4 and the interrogation

Trial Locations

Locations (1)

Centre Hospitalier Le Vinatier; 🇫🇷 Bron, Auvergne Rhone Alpes, France