AS-OCT Guided Treatment of Diffuse CSCC

Completed

• Conditions: Conjunctival Neoplasms

• Registration Number: NCT03515954
• Lead Sponsor: Benha University

Brief Summary

A prospective study was performed on 8 eyes of 8 patients who underwent amniotic membrane graft after diffuse conjunctival squamous cell neoplasia excision followed by topical mitomycin C 0.04% eye drop between March 2014 and January 2018.

Detailed Description

Surgical excision of the conjunctival tumour . A superficial corneal scraping was performed for corneal lesion then double freeze-thaw cryotherapy was applied to limbal edge and conjunctival margins.The amniotic membrane graft was secure and attached to the sclera and conjunctiva using fibrin glue.Topical mitomycin C 0.04%eye drop was prescribed 4 times daily per treatment cycle (1 cycle=1 week on 1 week off).

Study Timeline

• Study Start: 2014-03
• Primary Completion: 2018-01
• Study First Submitted: 2018-04-24
• Study First Submitted QC: 2018-04-24
• Study First Posted: 2018-05-04
• Study Completion: 2018-10
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-30
• Last Update Posted: 2019-01-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• diffuse Ocular Surface Squamous Neoplasia

Exclusion Criteria

• localized OSSN (less than five clock hours in limbal extent)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The recurrence rate of lesion	2 years	Any recurrence which is detected clinically or/and by AS-OCT